MedTech Show

Dentistry

Technology: AI Oral Health Platform

About:

Our artificial intelligence (AI) can analyze smartphone photographs and detect gum inflammation. Based on the photographs, our AI can detect “site-specific” gum inflammation and provide personalized advice on where to clean.
For dental professionals, our AI can help dentists design a natural-like tooth to replace missing teeth based on the feature of remaining dentition.

Person-in-charge:

Professor Walter Lam, Faculty of Dentistry

Technology: 3D Printed Piezoelectric Teeth Whitening Braces

About:

The project aims to develop an innovative 3D-printed mouth brace that enhances the teeth whitening process by utilizing a biocompatible piezoelectric effect, while ensuring a comfortable and personalized experience for users. Over-the-counter whitening products, such as toothpaste, strips, gels, and trays, contain high concentrations of hydrogen peroxide, carbamide peroxide, and abrasives, which can damage enamel, dentin, and soft tissues. Piezoelectric materials can produce reactive oxygen species (ROS) under the mechanical vibrations. The continuous generated ROS has a relatively low local concentration that will not damage teeth but can degrade stain molecules to whiten the teeth.

Person-in-charge:

Professor Ye Zhou, Faculty of Dentistry

Technology: Enabling biosafe monomers for dental and medical applications

About:

Commonly, photocurable and injectable medical and dental polymers and composites are made with dimethacrylate monomers, due to the cheap cost and the excellent mechanical properties. However, these monomers contain bisphenol-A (BPA) which is estrogenic and carcinogenic that has been banned in food and baby products. We have patented and developed series of biosafe BPA-free monomers with high biocompatibility and high strength, that can is ready for bone cements, dental composites, and 3D-print clear aligners formulations. We also have know-how technology on clean synthesis of these monomers.

Person-in-charge:

Professor James Tsoi, Faculty of Dentistry

Technology: Carbamylated erythropoietin for nerve regeneration

About:

Nerve injury is a common complication in oral and maxillofacial surgery. Erythropoietin is well known for its neuroprotective property, but the hematopoietic side effects hindered its clinical application in surgery. Carbamylated erythropoietin (CEPO) that retain the neuroprotection effect without hematopoietic effect, is hence target of our study, aiming on overcoming this hurdle. The effect of CEPO on Schwann cell-mediated healing of the peripheral nervous system and the mechanism of how CEPO possibly exerting its neuroprotective effect on Schwann cells have not been studied previously. The aim is to develop CEPO as a prospective therapeutic agent for nerve regeneration.

Person-in-charge:

Professor Yiu Yan Leung, Faculty of Dentistry

 

Looking for Talent:

Research assistant, with expertise in biological science and biochemistry and neuroscience

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Technology: Oral diagnostic devices: measuring inflammatory markers for Neutrophil characteristics in a chairside setting outside for non-dental and medical workforce

About:

For subjects who do not have easy access to dental care, a screening tool can be beneficial in the decision making for the need for dental treatment and diagnostics. The development of a chairside patient screening tool which allows patients or non-dental medical staff to measure oral health and oral inflammation can for instance be helpful for patients in a home/care setting. Oral leukocyte numbers and function, specifically neutrophils, retrieved from saliva correlate positively with the oral inflammatory load. Thus, saliva or oral rinse samples could potentially be used for screening of the oral health status in a non-invasive method.

Person-in-charge:

Professor Patrick Rijkschroeff, Faculty of Dentistry

Technology: 3D-printed smart orthodontic appliance equipped with nanodiamond optical sensors

About:

We developed smart 3D-printed orthodontic clear aligners with a built-in optical strain sensor for direct measurement of orthodontic forces and tooth movement. To establish an accurate force measurement method in a clinic, we integrate a clear aligner with nanodiamond optical strain sensors that can provide accurate digital information about the generated orthodontic forces (magnitude and direction). The developed technology is expected to dramatically improve the quality and outcome of orthodontic treatment acquiring the accurate orthodontic information. This technology has good translational potential and the potential for broad distribution via licensing and to create a significant market share in orthodontic appliances.

Person-in-charge:

Professor Kiho Cho, Faculty of Dentistry

 

Looking for Talent:

Co-founders including CEO and CFO for initial setup of the company (start-up).

Contact

 

Technology: Raman-activated Single-cell sorting of functional probiotics from nature

About:

Our groundbreaking technology uses Raman-activated single-cell sorting to efficiently screen functional probiotics from human microbiomes like feces and saliva. Focusing on Bifidobacterium spp., we identified key strains utilizing arabinan, addressing constipation in humans. Traditional microbiology methods face challenges in isolating strains with unique metabolic functions, prompting us to establish a Ramanomics platform at HKU. Employing a “screening-first-culture-next” strategy, our non-destructive method rapidly and high-throughputly sorts desired bacterial probiotics from in situ samples, overcoming key culturomics challenges in microbiome research. This transformative approach offers personalized and targeted probiotic interventions for gastrointestinal health.

Person-in-charge:

Professor Shi Huang, Faculty of Dentistry

 

Looking for Talent:

Technicians and students

Contact

 

Technology: Development of clinician-friendly software for 3D printed patient-specific surgical plates

About:

Patient-specific implants for reconstructive maxillofacial surgery in cancer patients preserve facial architecture and bite functionality. Traditional CAD software methods are time-consuming and require specialized knowledge. The newly developed software simplifies this process by utilizing a surface modeling approach that mimics the patient’s bone curvature, enabling rapid implant design in seconds. Additionally, the software recommends optimal design parameters to enhance functionality, making it a valuable tool for medical professionals in creating custom 3D-printed implants for their patients.

Person-in-charge:

Professor Richard Su, Faculty of Dentistry

 

Looking for Talent:

Technical team- Computer programming, Graphical Under interface development, Artificial intelligence- Machine learning, knowledge of computer-aided design framework. Can closely work with medical professionals.

Contact

 

Engineering

Technology: Photonic Chipscope for Monitoring of Live Cell Activities

About:

This inventive GaN chipscope provides a low-cost and ready-to-use sensing system for label-free cellular physiological activity detection. It comprises a monolithic gallium nitride (GaN) chip as a refractometer and a mini-differential interference contrast microscopy (DIC) component to realtime capture cellular/subcellular morphological features. The optoelectonic GaN chip integrates a light-emitting diode and a photodetector at a micro-scale, allowing for direct readout of local refractive index changes associated with cellular physiological activities. These unique properties make the GaN chipscope an ideal tool for real-time monitoring and quantifying cell activities in the biosensor field.

Person-in-charge:

Professor Zhiqin Chu, Faculty of Engineering

Technology: HealOR

About:

Healing healthcare units with efficiency, agility, and lean processes, Optimizing operations, and Rejuvenating the healthcare community. HealOR aims to empower hospitals and healthcare units to harness the power of digitalization, operations research and data science, to transform their processes operations and improve efficiency, patient care outcomes, and staff morale.

 

Person-in-charge:

Professor Yong-Hong Kuo, Faculty of Engineering

 

Looking for Talent:

  • Programmers
  • Operations Researchers

 

Contact

Technology: MicroDiagnostics – DipµChip

About:

DipµChip is a microfluidic chip which can perform ELISA in an automated and miniaturized method. DipµChip provides a plug-and-play and user-friendly design which makes it suitable for near-patient diagnostics applications. DipµChip requires only a drop of the patient’s whole blood and will be able to measure sepsis biomarkers – procalcitonin, interleukin 6 and c-reative protein – at picogram-level of sensitivity. DipµChip promises to be a point-of-care diagnostic tool which can give clinicians early detection of sepsis. This opportunity to treat sepsis patients earlier will not only improve health outcomes, but also reduce complications and the hospital’s overall cost of treatment.

Person-in-charge:

Professor Anderson Shum, Faculty of Engineering

 

Looking for Talent:

  • Biomedical Engineer

 

Contact

Technology: PERfECT-CGM for precision diabetes healthcare

About:

PERfECT-CGM for precision diabetes healthcare

Person-in-charge:

Professor Shiming Zhang, Faculty of Engineering

 

Looking for Talent:

  • CEO

 

Contact

Technology: Flexible microneedle electrodes for biopotential monitoring

About:

To ensure long-term biopotential monitoring with high-quality signals and minimal motion disruptions, the ideal solution lies in dry electrodes. Our team presents a novel, cost-effective, and scalable solution to surface biopotential monitoring by introducing highly conductive, flexible and ultra-thin microneedle electrodes (MNEs), fabricated using a 3D electrodeposition method. Unlike conventional Ag/AgCI gel electrodes, these MNEs eliminate the need for skin pre-treatment, discomfort, potential skin irritation, and the issue of signal degradation over time. Compared to existing dry electrodes, our invention overcomes the problems of high materials cost, low adhesiveness, and low flexibility. This innovative design ensures that the MNEs have excellent conductivity, adhere comfortably to the skin without causing pain, and maintain a high signal-to-noise ratio, marking a significant advancement in the field of wearable electrophysiology monitoring.

Person-in-charge:

Professor Wendi Li, Faculty of Engineering

 

Looking for Talent:

  • Working level or Student Intern: 1. Backgournd in Biomedical Engineering, Electrical Engineering, Computer Science, or a similar field. 2. Proficient in programming languages commonly used for data analysis and model development such as Python, R, or MATLAB. 3.Experience with data visualization tools and an understanding of user interface design for presenting health data and insights. 4.Knowledge of database management, data cleaning, and preprocessing techniques.

 

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Medicine

Technology: Precision Medicine for Nonalcoholic Steatohepatitis (NASH) and Liver Fibrosis

About:

The global prevalence of NAFLD is approximately 32% in the general population and up to 75% in the obese population. Whilst non-alcoholic fatty liver (NAFL) has a comparatively benign course, non-alcoholic steatohepatitis (NASH) and advanced fibrosis are the leading indications for liver-related mortality and transplantation. Early diagnosis of NASH is the key to control the progression of NAFLD. The biomarker-based non-invasive diagnostic methods we developed will be powerful tools for the diagnosis of NASH and liver fibrosis.

Person-in-charge:

Professor Aimin Xu, Faculty of Medicine

Technology: BayVax Biotech Limited

About:

BayVax Biotech Limited is committed to leveraging a generative AI-driven novel vaccine platform to program the immune system. This AI platform has expanded the boundaries of vaccines, extending from infectious disease preventive vaccines to personalized cancer vaccines. Our conjugate vaccine formulation, licensed from HKU, is designed to maximize the effectiveness of the generative vaccine. Our leading pipeline, neoantigen-based cancer vaccine, has started an investigator-initiated trial. We have received seed funding from MiraclePlus (formerly Y Combinator China) and to have been selected for the HKSTP Incubio Programme and ITC TSSSU+ Project.

Person-in-charge:

Professor Jian-Dong Huang, Faculty of Medicine

Technology: Targeting microglia as immunotherapies for the treatment of Alzheimer’s disease

About:

Alzheimer’s disease (AD) is the most common form of dementia currently affecting more than 10 million Chinese. AD interferes with patient’s daily activities, greatly decreases their quality of life and imposes a substantial cost on the healthcare system. Unfortunately, there are few approved therapies that can halt or reverse AD progression. Our previous works suggested that microglia, brain resident macrophages, maybe a potential target for therapeutic approaches to AD. In this proposal, we are going to generate the novel small molecules that target the immune receptors exclusively expressed by microglia and develop these drugs for AD therapy.

Person-in-charge:

Professor Shoutang Wang, Faculty of Medicine

Technology: Aptamer-based digital sensor for early sepsis diagnosis

About:

Our project leverages aptamer technology on electrochemical sensors for early sepsis diagnosis. Our rapid, accurate, and affordable solution eliminates the need for time-consuming lab tests, making it suitable for emergency rooms and hospital bedside use. Delayed sepsis diagnosis hinders timely treatment, leading to increased death rate. Our mission is to revolutionize early sepsis diagnosis with affordable aptamer-based solutions, saving lives by enabling timely intervention and optimized antimicrobial drug selection. With no similar offering in the market, we are poised to disrupt the field and provide a unique solution to improve patient outcomes.

Person-in-charge:

Professor Julian Tanner, Faculty of Medicine

Technology: Strostics

About:

Vision:
To develop Hong Kong’s first blood test for stroke

Mission:
To take our blood protein platform from discovery to market delivery for patient benefit

Product/Technology:
To develop a panel of blood markers, with high diagnostic and prognostic accuracy, delivering results in <5 minutes as point of care tests, useful within the first 24 hours os symptom onset in patients with stroke.

Person-in-charge:

Professor Timothy Rainer, Faculty of Medicine

 

Looking for Talent:

  • Executive level: Co-founder and Management Team, including Chief Executive Officer
  • Working level: Business Administration, Technical Officer
  • Student: PhD students

 

Contact

Technology: COMPASS Health Technology

About:

At COMPASS Health Technology, we harness the power of AI to create cutting-edge solutions for drug discovery and health management, aiming to tackle the urgent needs of the aging society. We are committed to developing a medication management system that utilizes artificial intelligence technology to ensure safe medication management for everyone in the ecosystem including medical professionals and individual patients.

Person-in-charge:

Professor Qingpeng Zhang, Faculty of Medicine

 

Looking for Talent:

  • Business partner
  • Admin

 

Contact

Technology: Post-Surgery AI

About:

Post-surgery AI is an AI predictive model to detect surgical site infections (SSI) earlier for patients in orthopaedics and general surgery wards to reduce the time to diagnosis and treatment. We collect data from electronic health records for risk factors of SSI, operation records, and postoperative monitoring (e.g. wound discharge fluid from surgical drains, wound location) to predict the possible microbes causing the infection and suggest the most appropriate antibiotic.

Person-in-charge:

Professor Jasper Chan, Faculty of Medicine

 

Looking for Talent:

  • Execute level: CTO (preferred background: Postgraduate level, AI/machine learning)
  • Working level: Machine learning Engineer, Data scientist

 

Contact

Technology: Cinnamaldehyde prodrugs

About:

The developed reactive oxygen species-responsive cinnamaldehyde-based polymeric prodrug can self-assemble into nanoparticles and accumulate at inflamed lesions and release cinnamaldehyde in response to the oxidative stress to inhibit the overproduction of inflammatory factors in situ, which can attenuate the progression of rheumatoid arthritis and ulcerative colitis. This system exhibits excellent drug stability, tissue selectivity, and controlled drug release upon oxidative stress activation. In the system, cinnamaldehyde, a food additive, is used as an anti-inflammatory therapeutic agent.

Person-in-charge:

Professor Weiping Wang, Faculty of Medicine

 

Looking for Talent:

Execute level: Co-founder, CEO
Working level: Business, Operations

Contact

Technology: mskalign® smart health service system and device

About:

mskalign® is the world’s leading smart health service system and device independently developed by CoNova Medical Technology and the Digital Health Laboratory of the Faculty of Medicine of the University of Hong Kong. It contains three major workbenches: PACS Al Quantitative Analysis Workbench, Wukong 3D Optical Alignment Workbench, and AlignPro Exercise Therapy And Tracking Workbench. mskalign® is based on ten years of clinical follow-up data and intelligent treatment planning centre, enabling Al-assisted accessible initial evaluation, 3D optical quantitative analysis, disease progression management, non-surgical treatment plan development and tracking, and many other effective clinical techniques. The “User-Expert Alliance” integrated online and offline services for remote musculoskeletal exercise and postoperative follow-up management.

Person-in-charge:

Professor Teng Zhang, Faculty of Medicine

 

Looking for Talent:

  • COO
    Applicants should possess a bachelor’s degree or above in science, engineering, medicine, or related disciplines, with a minimum of 5 years management experience in healthcare industry, prefer over 10 years experience. They should have a good command of written and spoken English and Chinese (including both Mandarin and Cantonese), in addition to excellent communication, organizational, problem-solving and project management skills.

 

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Technology: Organ-targeting nanocarrier delivery system

About:

Nanomedicine is a new promise for effective delivery of various drugs. Our group has previously developed the procedure for chemical labeling of HSA with specific cell targeting ligands and the preparation of drug-loaded HSA nanoparticles. This technology involves the construction of cell recognition ligand-proteins (e.g.,HSA)and the preparation of drug-loaded HSA nanoparticles for organ-targeting delivery. As a proof of principle, heart-targeting peptide (HTP) tagged HAS was prepared. Cardioprotective isoflavone puerarin has been loaded into HSA-HTP nanoparticles. Intraperitoneal administration allowed the accumulation of HSA-HTP fusion proteins in the heart. Puearin-loaded HSA-HTP nanoparticles will be evaluated for cardioprotective potential in myocardial infarction. This technology will be applied for delivery of different cardioprotective, neuroprotective and anticancer drugs.

Person-in-charge:

Professor Jianhui Rong, Faculty of Medicine

 

Looking for Talent:

  • Technical

 

Contact

Technology: Neuromuscular organoids

About:

We used Spinal Muscular Atrophy patients’ urine cells to generate 3D neuromuscular organoids that can reflect disease severity and identify new pathogenic factors and therapeutic targets via single-cell transcriptomics to fill the current treatment gaps.

Person-in-charge:

Professor Martin Cheung, Faculty of Medicine

 

Looking for Talent:

  • Research Assistant for routine generation of SMA patients-derived neuromuscular organoids (NMOs)
    People with expertise in the commercialization of our NMO technology pipeline.

 

Contact

Technology: Development of Instant Language Translation Platforms of Medical Consultations and Information

About:

Medical doctors in Hong Kong still need to manually type medical consultation notes in electronic health records after seeing patients. It is almost impossible to immediately translate the medical symptoms/signs of Chinese-speaking patients and some important medical terms from Chinese into English or other languages, without personal and manual interpretation of medical doctors. We aimed to develop an instant medical translation platform with AI so that once the patients and doctors talk about the symptoms/signs, medical findings or scan the reports in the platform, a written narrative or report in different languages of the users’ choice can be generated. In the long run, our platform shall also be able to generate differential diagnoses of patients’ presenting symptoms, formulate initial treatment and management plan, in both written, pictorial and video presentations.

Person-in-charge:

Professor Victor Lee, Faculty of Medicine

 

Looking for Talent:

  • Working level: business operations, AI technician
    Student interns: AI machine learning and training

 

Contact

Technology: Trophy Life Technology Limited

About:

Trophy Life aims to revolutionize the field of anti-viral drug discovery and neutral pharmaceutical product development by harnessing cutting-edge drug discovery and testing technology based on the patented technology in Expanded Potential Stem Cells (EPSCs). Building upon the groundbreaking research conducted within CTSCB for more than three years, Trophy Life is poised to emerge as a leading player in the industry. With a steadfast commitment to innovation and collaboration, Trophy Life is dedicated to making a lasting impact in the field of stem cell technology with innovative solutions. By combining the expertise of its team with the resources and network of CTSCB, the company is well-positioned to spearhead transformative advancements and to contribute to the development of effective anti-viral medications.

Person-in-charge:

Professor Pengtao Liu, Faculty of Medicine

 

Looking for Talent:

  • CFO or BD officer: Business development, marketing exploring & legal issues
  • PDF or RA: R&D, Product design, Lab management

 

Contact

Technology: BiomOrgan, A Pathfinder of Organoid Technology

About:

Introducing BiomOrgan, the pioneer and pathfinder of organoid technology. With four patents covering the methods of making and using nasal organoids, airway organoids, alveolar organoids, and organoid-based virus isolation, we lead the world in respiratory organoid technology. Our team consists of top organoid scientists and experienced entrepreneurs with abundant resources. Our mission is to position Hong Kong and the Greater Bay Area (GBA) as a leading international hub for organoid technology. By creating a Hong Kong brand and setting a benchmark in the global organoid market, we aim to showcase the excellent model of strategic cooperation within the GBA.

Person-in-charge:

Professor Jie Zhou, Faculty of Medicine

Technology: An Innovative Herbal Therapeutic Treatment of Mild Cognitive Impair (MCI) and Alzheimer’s Disease (AD)

About:

Introducing our innovative approach to detecting and preventing the progression of Mild Cognitive Impairment (MCI) to Alzheimer’s disease (AD). We have developed an AI-aided diagnostic platform, MAP, which utilizes blood routine tests to screen individuals with MCI who are likely to develop AD. Furthermore, we have obtained patents for our herbal composition, Brain X, specifically designed to treat MCI/AD. Preliminary clinical test results have shown promising outcomes, comparable to FDA-approved antibodies in reducing Amyloid-β in AD mouse brains. By integrating AI into chronic disease management, we not only improve symptoms but also offer preventative measures, bringing significant social and economic benefits.

Person-in-charge:

Professor You-qiang Song, Faculty of Medicine

Science

Technology: Design of Metal–Organic Framework Photocatalysts for Organic Synthesis

About:

After establishing an independent team at the University of Hong Kong, Dr. He seeks to develop interdisciplinary research programs at the interface between organic chemistry, inorganic chemistry, and materials science, with a focus on design of novel framework-based catalysts for the advancement of sustainable organic synthesis. Several heterogeneous platforms based on metal‒organic frameworks (MOFs) have been developed to facilitate photoinduced copper-catalyzed organic reactions. For instance, we immobilized a binap-ligated copper(I) dimer on a modifiable pillar-layered MOF matrix to prepare a robust heterogeneous copper photoredox catalyst. In comparison to its homogeneous counterparts, the MOF-supported copper photocatalyst exhibits superior catalytic performance and promotes iminyl-radical coupling reactions with low copper loadings. Recently, they successfully prepared stable heterogeneous copper triplet photosensitizers by integrating binap-ligated heteroleptic copper(I) complexes in the pores of phenanthroline-functionalized UiO-69 MOFs. The substrate scope for [2+2] cycloadditions can be expanded beyond what was attainable in previous homogeneous catalysis.

Person-in-charge:

Professor Jian He, Faculty of Science

Technology: Specific Production of “Last-line Antibiotic” Colistin A in Paenibacillus Polymyxa Through Integrated Bioengineering Strategies

About:

Millions of lives are tragically lost each year due to the devastating impact of multi-drug resistant (MDR) Gram-negative bacterial infections. In combating this urgent global health crisis, Colistin has emerged as a crucial “last-line antibiotic” with low drug resistance rates against Gram-negative pathogens. Our project addresses the pressing issue of superbug resistance by utilizing advanced metabolic engineering techniques to produce pharmaceutical-grade Colistin efficiently. Through the integration of cutting-edge disciplines such as synthetic biology, metabolic engineering, and fermentation engineering, we are committed to developing a groundbreaking solution that surpasses the stringent requirements of the British and European Pharmacopoeia. This innovative approach will enable us to produce Colistin with exceptional titer and purity, providing an effective and cost-efficient Active Pharmaceutical Ingredient (API) urgently needed to combat MDR Gram-negative bacterial infections.

Person-in-charge:

Professor Yong-Xin Li, Faculty of Science

 

Looking for Talent:

  • Student Intern:
    We are looking for student intern with a basic understanding of business concepts, such as marketing, finance, and negotiation skills. The student intern should be comfortable attending industry or commecial events and representing our start-up in a decent manner. A candidate who is proactive in building professional networks to connect with potential customers or investors, or developing strategies for business growth would be preferred.

 

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Technology: SeriTide Discovery Biotechnology

About:

Establish an innovative peptide-based drug discovery and development center, by streamlining synthesis, structural modification and screening platform

Person-in-charge:

Professor Xuechen Li, Faculty of Science

 

Looking for Talent:

  • CEO

 

Contact

Technology: careEASY Smart AI healthcare workforce solution

About:

careEASY is a next-generation all-in-one personalized health platform that connects clients with nursing needs, assisted living individuals, hospitals to the highest quantity and quality of licensed nurses (EN, RNs). As the #1 healthcare jobs mobile app on the App Store with over 1000 nursing professionals, careEASY serves our healthcare institution partners by offering cloud-based AI workforce hospital staffing and roster management solutions and direct access to labor. The on-demand smart platform dramatically streamlines the delivery of care services and enables client an hospitals access to compliant, qualified professionals to fulfill their healthcare staffing needs faster and efficiently than traditional solution.

Person-in-charge:

Professor Rocky Law, Faculty of Science

Technology: Miniature diagnostic devices for disease with DNA damage

About:

We aims to utilize novel illuminating materials to develop and manufacture a series of miniature diagnostic devices for various analytical applications. We have made our preliminary functional prototype spectral sensor, with a size of 1 cm×1 cm, range from 230 to 1700 nm and cost under HK$200. Our prototype product has widest wavelength coverage, smallest size and lowest affordable price compared with other competitive products in markets. We will further optimize our prototype sensor and combined them with DNA damage probe compound (Intellectual Property owned by HKU) to develop point-of-care devices for early cancer detection.

Person-in-charge:

Professor Wei Liu, Faculty of Science